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On December 16, 2004, on the basis of these findings, the advice of the cardiovascular safety committee, and previous findings with drugs in the same class, the data and safety monitoring board concluded that continued exposure to celecoxib placed patients at increased risk for serious cardiovascular events.

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Recently, however, this class of drugs has come under scrutiny because of clinical reports that they were associated with an increased risk of serious cardiovascular harm.

The incidence of clinically important gastrointestinal events was lower in the rofecoxib group than in the naproxen group in all subgroups we examined.

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Published on  December 4th, 2016

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